![]() ![]() The study confirms that both the Pfizer and Moderna vaccines are highly effective, with low risks of breakthrough infections and other COVID-19 outcomes.Īccording to early randomized trials, the Pfizer and Moderna vaccines have demonstrated more than 90 percent effectiveness for preventing symptomatic COVID-19. The large size of the study population also allowed researchers to provide precise estimates for severe COVID-19 outcomes. The study’s design enabled the researchers to directly compare the effectiveness of the Pfizer and Moderna vaccines in a real-world setting, in diverse subgroups, and across different periods when the Alpha or Delta variants were predominant. Vaccinated shed virus for shorter period of time, less likely to spread COVID “This is something that we are actively investigating.” “That said, any choice between vaccines must also consider their comparative safety, which was not studied here,” Dickerman added. While the identified differences in estimated risk were small on the absolute scale, they may be meaningful for larger decision-making bodies, such as health care systems and higher-level organizations, when considering the large population scale at which these vaccines are deployed. “However, this large-scale study allowed us to detect subtle differences between these two highly effective vaccines. ![]() “Given the high effectiveness of both vaccines, either one is strongly recommended to any individual offered the choice between the two,” said first author Barbra Dickerman, CAUSALab investigator and instructor in the Department of Epidemiology at Harvard Chan School. The study was published online Wednesday in the New England Journal of Medicine. This pattern was consistent for periods when Alpha or Delta were the predominant variant. Compared with the Pfizer COVID-19 vaccine, the Moderna COVID-19 vaccine has a slightly lower risk of COVID-19 outcomes, including documented SARS-CoV-2 infection, symptomatic COVID-19, and COVID-19-related hospitalization, intensive care unit admission, and death, over a 24-week period, according to a team of researchers. ![]()
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