The data cutoff for the primary analysis occurred on November 25, 2020. No other potential conflict of interest relevant to this article was reported. Zaks, being employed by and owning stock options in Moderna. Miller, being employed by and owning stock and stock options in Moderna and Dr. Ivarsson, being employed by and owning share options in Moderna Dr. Han, being employed by and owning stock and stock options in Moderna Dr. Leav, Deng, and Zhou being employees of Moderna Dr. Knightly, being employed by and owning stock and stock options in Moderna Drs. Pajon, being employed by and owning stock in Moderna Dr. Bennett, being employed by and owning stock and stock options in Moderna Dr. Graham, holding pending patent WO/2018/081318 on prefusion coronavirus spike proteins and their use and pending patent 62/972,886 on 2019-nCoV vaccine Dr. Neuzil, receiving grant support from Pfizer Dr. Creech, receiving grant support from Merck, consulting fees from Horizon Pharma and GSK, and fees for serving on a data and safety monitoring board from Astellas Dr. Rouphael, receiving grant support from Pfizer, Merck, Sanofi–Pasteur, Eli Lilly, and Quidel Dr. Baden reports being funded by the NIH to conduct clinical trials in collaboration with Crucell/Janssen and Moderna Dr. (Funded by the Biomedical Advanced Research and Development Authority and the National Institute of Allergy and Infectious Diseases COVE number, NCT04470427.).Ĭopyright © 2020 Massachusetts Medical Society.ĭr. Aside from transient local and systemic reactions, no safety concerns were identified. The mRNA-1273 vaccine showed 94.1% efficacy at preventing Covid-19 illness, including severe disease. Serious adverse events were rare, and the incidence was similar in the two groups. Moderate, transient reactogenicity after vaccination occurred more frequently in the mRNA-1273 group. Severe Covid-19 occurred in 30 participants, with one fatality all 30 were in the placebo group. Efficacy was similar across key secondary analyses, including assessment 14 days after the first dose, analyses that included participants who had evidence of SARS-CoV-2 infection at baseline, and analyses in participants 65 years of age or older. person-years 95% confidence interval, 48.7 to 65.3) and in 11 participants in the mRNA-1273 group (3. Symptomatic Covid-19 illness was confirmed in 185 participants in the placebo group (56. More than 96% of participants received both injections, and 2.2% had evidence (serologic, virologic, or both) of SARS-CoV-2 infection at baseline. The trial enrolled 30,420 volunteers who were randomly assigned in a 1:1 ratio to receive either vaccine or placebo (15,210 participants in each group). The primary end point was prevention of Covid-19 illness with onset at least 14 days after the second injection in participants who had not previously been infected with SARS-CoV-2. Persons at high risk for SARS-CoV-2 infection or its complications were randomly assigned in a 1:1 ratio to receive two intramuscular injections of mRNA-1273 (100 μg) or placebo 28 days apart. This phase 3 randomized, observer-blinded, placebo-controlled trial was conducted at 99 centers across the United States. The mRNA-1273 vaccine is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19. Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications.
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Express Shipping is Available Worldwide | 74.95$ with UPS or FedEx, takes from three days to a week and a half to arrive.Expedited hipping is Available in Australia, Canada, and the United States of America | 49.95$, takes from two to five weeks to arrive.Once you approve the pictures, we send your sword by either our Expedited or our Express Service. There are big-size pictures taken from the front, from the side, and the top… And also close-ups of most angles. Your custom katana isn’t shipped until we get your full approval for the sword’s looks. We always do many angles to make sure everything is exactly as you ordered. Once the sword is ready and assembled, we take its pictures. We send you pictures of your katana sword for approval For more complex swords (in 15% of cases), it can take us around three-four weeks, up to at most six to have it assembled. In these cases, the full assembly of the sword takes from one to two weeks. 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If you believe your animal has been brought to the Shelter please contact the Shelter directly to reclaim the animal.Fill out an application by clicking here and email the application to After filling out the application call the shelter, 60, to make sure the application was received and to be scheduled an appointment to meet with that particular animal.Go to to view the available animals we have for adoption.Animals can not be shown out of the cage until you have a completed and reviewed application. If you are coming in to fill out an application in person instead of online to be preapproved, please come prepared with pet policy information (if you rent) and vet records (if you own or have recently owned an animal) to be able to expedite the application process. Please find below the steps listed to schedule an appointment to adopt and view an animal. Wednesday- CLOSED for public walk throughs appointments only Hours of operation for public walk through are as follows: Finally, we rescue animals from animal control facilities whose time has run out and bring them to our facility for another chance at finding a forever home.SHELTER HOURS OF OPERATION/ ANIMAL VIEWING UPDATE We offer humane education to the public on how to be responsible pet owners. Our low cost clinic offers affordable spay/neuter services as well as other comprehensive veterinary care. There are many ways we go about accomplishing this. Valley Animal Center is taking the lead on reducing the use of euthanasia and to help decrease the stray population. Valley Animal Center, along with numerous no-kill shelters in the area, are working together to try and stop the use of euthanasia by rescuing animals from animal control agencies. a temperate Central Valley climate which has allowed for higher than average reproductive rates.insufficient public awareness regarding the importance of spaying and neutering.a historical lack of a progressive animal welfare presence.A variety of factors have contributed to the severe overpopulation and under-adoption of dogs and cats. For years, Fresno County's animal control agencies have been overburdened with stray and surrendered dogs and cats. Our high stray population contributes to this dilemma. The Greater Fresno Area has long had a need for no-kill humane efforts due to the unfortunate fact that the San Joaquin Valley has one of the highest euthanasia rates in the United States. Thanks to the generosity and support of the community, along with the dedication and hard work of countless volunteers and staff members, this humble, no-kill cat sanctuary grew to include a low-cost spay and neuter clinic and eventually became a no-kill shelter for dogs, also. In 1992, Valley Animal Center's predecessor, the California Feline Foundation, was founded in Downtown Fresno as a no-kill shelter for cats. Antimicrobial flooring throughout the facility, along with an air-ventilation system which completely exchanges the air in all animal areas, are in place to combat the spread of any illnesses that may arise. All employees adhere to strict cleaning and maintenance protocol. Separate dog and cat living quarters allow indoor/outdoor access and exposure to fresh air and natural sunlight. Our state-of-the-art Dog and Cat Adoption Centers emphasize comfortable and sanitary conditions. Unlike traditional shelters, no funds are received from government sources. Financial support is derived solely through donations from the community, grants, program services, and fundraising efforts. Valley Animal Center is a community-supported organization. Euthanasia is performed only when an animal is suffering from a serious illness that cannot be cured or is in such a painful condition that cannot be alleviated.ĭay-to-day shelter capacity can comfortably accommodate more than 100 dogs and 300 cats, and our emergency capacity can accommodate 200 dogs and 500 cats. Even those once considered un-adoptable due to their medical conditions or disabilities have been rehabilitated and, ultimately, adopted into loving families.Īs a no-kill shelter, any animals we take in stay with us until they have found a furever home. Both dogs and cats are spayed or neutered, fully vaccinated, microchipped, and administered any additional medical care as needed. Upon entering the shelter, cats are tested for Feline AIDS and Feline Leukemia. |
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